So I know this has been discussed ad nauseum in the past. But! This layout is giving me fits. I'm trying to decide how to space the lighting, and am open to all sort of suggestions...

So the gray box in the middle is a skylight, the empty spot above is the sink. The perimeter solid lines are the cabinets, while the dotted lines are the counters. The solid box to the right of the skylight is where the fridge protrudes past the counters... Black dots are a general idea of what I am thinking as far as recessed lights (Not installed) that would be replacing the 80's style tube lighting currently present. The random box at the bottom of the picture is a chandelier in the dining room that will be replaced and can be moved over slightly either way if needed. I plan on added recessed to the dining room as well (on its own switch) for when I really want to light up. My issue is trying to figure out what to center off of. The skylight is slightly off center of the room, but i feel like it would be best to measure out from it for the recessed lighting to better appear symmetrical. Though if I do so and keep the pattern of recessed lights into the dining room, it will be more obvious that the lights aren't evenly spaced from the walls...

The bottom left recessed light may very well turn into dual pendants over the protruding counter/island, and am thinking that would allow some break in the monotony to then switch it up a bit? Again, over thinking I know. But any and all suggestions are welcome. Please use the picture as a reference for what you would do and scribble it up if needed.

Standard 8 foot ceiling

The only thing the lady wants to stay is skylight and chandelier, the rest is up for debate.

 

My opinion.
"it will be more obvious that the lights aren't evenly spaced from the walls..."
I would space off the wall edges.
Another possible idea but will involve more work might be perimeter lighting or possible track lighting.